Stumped

The national financial panics of the mid-1800's were devastating to many families. Due to widespread bankruptcies, foreclosures, and unemployment, more than a few men went West to repair their financial fortunes. Not all of these men were prepared for the loneliness and hardships, and some were never heard from again. Depression wasn't a common diagnosis at the time, but there may be some cause to wonder how many accidental falls, drownings, and fatal gunshot wounds were 'accidents' after all.
"From my Western abode,I'd pay debts agreeably owed,And repair my reputation among men.But the Trail's truth declared,A Pioneer unprepared,Is unlikely to be heard from again."